![]() ![]() Secretion of aldosterone is also directly stimulated by hyperkalaemia. This is secreted in response to angiotensin II, produced as a result of the activation of the renin–angiotensin system by a decrease in renal blood flow and other indicators of decreased extracellular fluid (ECF) volume (Fig. The most important mineralocorticoid is aldosterone. Corticosterone, a precursor of aldosterone, is a weak glucocorticoid (30% of the activity of cortisol).įigure 8.1 Principal physiological functions of glucocorticoids. 8.1) and are particularly important in mediating the body’s response to stress. Cortisol exerts negative feedback control on ACTH release through inhibiting the action of CRH it also inhibits CRH secretion. Glucocorticoids, of which the most important is cortisol, are secreted in response to adrenocorticotrophic hormone (ACTH), which is itself secreted by the pituitary in response to the hypothalamic corticotrophin releasing hormone (CRH). ![]() ![]() The medulla, which is functionally part of the sympathetic nervous system, is not essential to life, and its pathological importance is related mainly to the occurrence of rare catecholamine-secreting tumours. The adrenal cortex is essential to life it produces three classes of steroid hormone: glucocorticoids, mineralocorticoids and androgens. The adrenal glands have two functionally distinct parts: the cortex and the medulla. ![]()
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